The question about the origin of life is a rational consequence observing different organisms in nature and not at least recognizing ourselves as living beings. Science is searching for answers based on empirical results interpreted in a naturalistic way. What is the scientific concept for life? Can life be reducible to a complex chemical reaction system or is it a phenomenon based on a genome? Which models about the origin of life are currently discussed? Are there scienctific models answering these questions really solid? Can we construct a path from a mixture of chemicals to a system mentioned living system? Are there plausible steps from a soup to first cell-like systems? Are there already successful experiments to create life in the lab? Is life on earth a consequence of an infection from the interstellar space? Louis Pasteur, a 19th century microbiologist, demonstrated „omne vivum ex vivo“ (i.e.all life comes from life). Are there evidences for any exceptions? The lecture will present some of the different evolutionary concepts of the origins of life and discuss them in a critical way.